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In men, FSH primarily binds to which cells to promote spermatogenesis?

ALeydig cells
BSertoli cells
CSpermatogonia directly
DEpididymal epithelial cells
Answer & Solution
Correct answer: B. Sertoli cells
1. LH and FSH act on different testicular cell types. 2. LH binds to Leydig cells to stimulate testosterone production. 3. FSH instead binds predominantly to Sertoli cells within the seminiferous tubules. 4. This FSH-Sertoli signalling promotes spermatogenesis and stimulates inhibin production. 5. So Sertoli cells, not Leydig cells, are the target of FSH. _Source: OpenStax Anatomy and Physiology (CC BY 4.0), Ch 27 "The Reproductive System", p.1290 §Control of Testosterone_
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