Enhancers are eukaryotic DNA sequences that boost transcription of a gene. How far can an enhancer be located from the gene it affects?

1. Enhancers are regions that help increase or enhance transcription and are not necessarily close to the genes they affect. 2. They can be located upstream of a gene, within its coding region, downstream of it, or thousands of nucleotides away. 3. Because DNA is a three-dimensional object, a distant nucleotide sequence can fold over and interact with a specific promoter. 4. Restricting enhancers to a location immediately adjacent to the start site or only within the coding region ignores the range of positions described for them. 5. Enhancer position is not limited to a different chromosome only; enhancers are also described as occurring on the same DNA molecule at varying distances. _Source: OpenStax Biology (1st ed., CC BY 4.0), Ch 16 "Gene Expression", section Enhancers and Transcription_