The gene myc encodes a transcription factor that becomes an oncogene when aberrantly activated. With which cancer is overexpression of myc associated?
ALupus erythematosus
BColon cancer only
CBurkett's lymphoma
DRheumatic fever only
Answer & Solution
Correct answer: C. Burkett's lymphoma
1. Proto-oncogenes are positive cell-cycle regulators that can become oncogenes when mutated.
2. Myc is a transcription factor that is aberrantly activated in Burkett's lymphoma, a cancer of the lymph system.
3. Overexpression of myc transforms normal B cells into cancerous cells that grow uncontrollably.
4. Systemic lupus erythematosus and rheumatic fever are autoimmune conditions discussed in a different chapter, not cancers linked to myc.
5. Colon cancer is instead linked to the c-Flip protein's long form, not to myc overexpression.
_Source: OpenStax Biology (1st ed., CC BY 4.0), Ch 16 "Gene Expression", section Tumor Suppressor Genes, Oncogenes, and Cancer_
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