Which cell surface receptor does HIV bind to on T cells?
AThe LDL receptor protein
BThe CD4 receptor protein
CThe aquaporin channel
DThe clathrin coat protein
Answer & Solution
Correct answer: B. The CD4 receptor protein
1. HIV penetrates the plasma membranes of a subtype of lymphocytes called T-helper cells.
2. It does so by binding to the CD4 receptor, a glycoprotein on the surfaces of T cells.
3. The LDL receptor clears low-density lipoprotein from the blood by receptor-mediated endocytosis, an unrelated pathway.
4. Aquaporins are water channels and clathrin is a coat protein, so neither is a viral binding site.
_Source: OpenStax Biology (1st ed., CC BY 4.0), Ch 5 "Structure and Function of Plasma Membranes", section 5.1 Components and Structure_
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