What share of circulating EPO comes from the kidney, and what does the hormone do?
A85 percent, stimulating red cell formation
B15 percent, stimulating red cell formation
C85 percent, stimulating platelet formation
D50 percent, stimulating white cell formation
Answer & Solution
Correct answer: A. 85 percent, stimulating red cell formation
1. EPO is a 193 amino acid protein that stimulates red blood cell formation in the bone marrow.
2. The kidney produces 85 percent of the circulating hormone and the liver produces the remainder.
3. That is why renal failure, which costs the body its EPO production, is associated with anemia.
4. Platelet and white cell production are driven by other factors entirely.
_Source: OpenStax Anatomy and Physiology (CC BY 4.0), Ch 25 "The Urinary System", section 25.10 The Urinary System and Homeostasis_
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