alleryStart learning →Which drugs cannot be cleared by glomerular filtration?
ASmall water-soluble molecules such as sugars
BWeak bases such as dopamine and histamine
CLarge molecules and those bound to proteins
DWeak acids such as penicillin and indomethacin
Answer & Solution
Correct answer: C. Large molecules and those bound to proteins
1. The glomerulus filters by size, and it holds plasma proteins back entirely.
2. A drug that is itself large, such as heparin, cannot cross.
3. A drug bound to a plasma protein travels with a carrier too big to cross, so it cannot be filtered either.
4. Such drugs are not readily eliminated by filtration and must leave by other routes.
5. Basic drugs like dopamine and acidic drugs like penicillin have specific carriers that secrete them into the tubule lumen.
_Source: OpenStax Anatomy and Physiology (CC BY 4.0), Ch 25 "The Urinary System", section 25.9 Regulation of Fluid Volume and Composition_
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