alleryStart learning →Which three signs did clinicians once use to identify diabetes mellitus?
APolyuria, pallor and polyphagia
BPolydipsia, pallor and polyuria
CPolyphagia, pruritus and polyuria
DPolyuria, polydipsia and polyphagia
Answer & Solution
Correct answer: D. Polyuria, polydipsia and polyphagia
1. Before glucose could be measured in blood and urine, the diagnosis rested on three signs.
2. Polyuria is the increased urine output driven by unrecovered glucose acting osmotically.
3. Polydipsia is the increased thirst that follows the water loss.
4. Polyphagia is the increased hunger, since cells cannot take up the glucose that is available.
5. Pallor is not one of the three and belongs to no part of this triad.
_Source: OpenStax Anatomy and Physiology (CC BY 4.0), Ch 25 "The Urinary System", section 25.9 Regulation of Fluid Volume and Composition_
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