Why is mannitol given after a head injury?
AIt blocks sodium recovery in the distal tubule
BIt replaces the plasma proteins lost in injury
CIt draws water off osmotically to cut swelling
DIt raises renal blood flow by dilating vessels
Answer & Solution
Correct answer: C. It draws water off osmotically to cut swelling
1. Mannitol is an indigestible sugar and acts as an osmotic diuretic.
2. Osmotic diuretics promote water loss by osmosis rather than by blocking a transporter.
3. That osmotic pull is used to reduce brain swelling after head injury.
4. Unrecovered glucose in poorly controlled diabetes acts as a powerful osmotic diuretic in exactly the same way.
_Source: OpenStax Anatomy and Physiology (CC BY 4.0), Ch 25 "The Urinary System", section 25.9 Regulation of Fluid Volume and Composition_
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