How does progesterone affect renal sodium and water handling?
AIt binds the aldosterone receptor weakly
BIt blocks the ADH receptor in the ducts
CIt raises renin output from the kidney
DIt inhibits ACE activity in the lungs
Answer & Solution
Correct answer: A. It binds the aldosterone receptor weakly
1. Progesterone is a steroid built on a structure very close to that of aldosterone.
2. That similarity lets it bind the aldosterone receptor in the collecting duct.
3. Binding there weakly stimulates sodium reabsorption and water recovery.
4. The effect is unimportant in men because circulating progesterone is low, but it can add water retention during parts of the menstrual cycle.
_Source: OpenStax Anatomy and Physiology (CC BY 4.0), Ch 25 "The Urinary System", section 25.8 Endocrine Regulation of Kidney Function_
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