alleryStart learning →Which cells produce renin, and what stimulates its release?
AGranular cells, on falling extracellular volume
BMacula densa cells, on rising sodium delivery
CAdrenal cortex cells, on rising angiotensin II
DPrincipal cells, on falling plasma potassium
Answer & Solution
Correct answer: A. Granular cells, on falling extracellular volume
1. Renin is an enzyme produced by the granular cells of the afferent arteriole at the juxtaglomerular apparatus.
2. Prostaglandins and nitric oxide from the apparatus stimulate its release.
3. The trigger behind those signals is a decrease in extracellular fluid volume, which shows up as falling blood pressure.
4. Macula densa cells regulate that release, but the enzyme itself comes from the granular cells.
_Source: OpenStax Anatomy and Physiology (CC BY 4.0), Ch 25 "The Urinary System", section 25.8 Endocrine Regulation of Kidney Function_
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