alleryStart learning →What part does nitric oxide play in tubuloglomerular feedback?
AIt constricts the afferent arteriole strongly
BIt replaces adenosine as the main constrictor
CIt blocks renin release from the granular cells
DIt relaxes the afferent arteriole, fine-tuning
Answer & Solution
Correct answer: D. It relaxes the afferent arteriole, fine-tuning
1. Tubuloglomerular feedback uses three paracrine signals: ATP, adenosine and nitric oxide.
2. ATP and adenosine constrict the afferent arteriole and slow filtration.
3. Nitric oxide pulls the other way, relaxing the same arteriole at the same time.
4. Working against the constrictors, it fine-tunes their effect rather than reversing it outright.
5. Calling nitric oxide a constrictor would leave the loop with no opposing signal at all.
_Source: OpenStax Anatomy and Physiology (CC BY 4.0), Ch 25 "The Urinary System", section 25.7 Regulation of Renal Blood Flow_
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