alleryStart learning →What reaction does renin catalyse?
AIt converts angiotensin I into angiotensin II
BIt releases aldosterone from adrenal cortex
CIt converts calcidiol into active calcitriol
DIt cleaves angiotensinogen to angiotensin I
Answer & Solution
Correct answer: D. It cleaves angiotensinogen to angiotensin I
1. Renin is a 304 amino acid protein released by the juxtaglomerular cells.
2. It cleaves several amino acids from circulating angiotensinogen, producing angiotensin I.
3. Angiotensin I has no biological activity of its own.
4. The next step, conversion into angiotensin II, is carried out by ACE from the lungs and not by renin.
5. Aldosterone release follows further down the cascade, driven by angiotensin II acting on the adrenal cortex.
_Source: OpenStax Anatomy and Physiology (CC BY 4.0), Ch 25 "The Urinary System", section 25.4 Microscopic Anatomy of the Kidney_
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