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Acetophenone (C₆H₅COCH₃) can be prepared by Friedel-Crafts acylation of benzene with:
ACH₃OH / AlCl₃
BCH₃Cl / AlCl₃ (Friedel-Crafts alkylation — gives ethylbenzene, not the ketone)
CCH₃COCl / AlCl₃ — anhydrous; product is acetophenone (phenyl methyl ketone)
DCH₃COOH / H₂SO₄
Answer & Solution
Correct answer: C. CH₃COCl / AlCl₃ — anhydrous; product is acetophenone (phenyl methyl ketone)
**Friedel-Crafts acylation**: ArH + RCOCl (or (RCO)₂O) + **AlCl₃** → Ar-CO-R (aryl ketone). For acetophenone: benzene + **CH₃COCl/AlCl₃** → **C₆H₅COCH₃**. Anhydrous conditions required. Friedel-Crafts alkylation gives polysubstitution and rearrangements — acylation avoids both.
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