**Helper T cells (CD4⁺)** in the immune system primarily:
ADirectly kill virus-infected cells
BCoordinate the immune response by secreting cytokines that activate B cells, cytotoxic T cells and macrophages
CProduce antibodies
DAre part of innate immunity only
Answer & Solution
Correct answer: B. Coordinate the immune response by secreting cytokines that activate B cells, cytotoxic T cells and macrophages
CD4⁺ helper T cells: recognise antigen on MHC II presented by APCs; secrete cytokines (IL-2, IFN-γ, etc.) → activate B cells (antibody production), CD8 cytotoxic T cells, and macrophages. HIV's catastrophic effect: depletes CD4⁺ cells → entire adaptive immunity collapses.
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