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Modern biotechnological vaccines are considered safer than traditional ones mainly because they:

AContain no antigen substance of any kind
BUse only living unmodified disease pathogens
CUse lab-made antigen proteins, not whole pathogens
DMust always be stored deep-frozen to work
Answer & Solution
Correct answer: C. Use lab-made antigen proteins, not whole pathogens
1. Traditional vaccines used killed or semi-killed pathogens, which carried a risk of causing the disease. 2. Biotechnological vaccines use antigen proteins produced in the laboratory from a gene of the pathogen, removing that risk. 3. They are not made of living unmodified pathogens, and they must contain antigen to trigger immunity, so those options are wrong. 4. These vaccines are described as more thermo-stable, contradicting the must-be-frozen claim, which is a trap. _Source: Balbharati (Maharashtra Board) Class 10 Science & Technology Part 2, Ch 8 "Cell Biology and Biotechnology", p.102_
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