alleryThe drug CISPLATIN has the formula [Pt(NH3)2Cl2]. Its anti-cancer activity comes from the:
ATrans isomer (NH3 groups opposite)
BMixture of cis + trans isomers
CTetrahedral geometry of platinum
DCis isomer (NH3 groups adjacent)
Answer & Solution
Correct answer: D. Cis isomer (NH3 groups adjacent)
Only the CIS isomer of [Pt(NH3)2Cl2] (CISPLATIN) is biologically active and used in cancer chemotherapy.
The trans form is inactive.
Square planar geometry allows cis-trans isomerism.
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