alleryIn sickle-cell anaemia the mutation substitutes which amino acid in the beta chain of haemoglobin?
AGlutamic acid is replaced by valine
BValine is replaced by glutamic acid
CGlutamine is replaced by lysine
DGlycine is replaced by alanine
Answer & Solution
Correct answer: A. Glutamic acid is replaced by valine
The single base substitution (GAG to GUG) changes codon 6 of the beta globin chain, replacing glutamic acid with valine.
The altered haemoglobin polymerises under low oxygen, distorting RBCs into the sickle shape.
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