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The osmolarity of the medullary interstitium ranges approximately from

A50 to 150 mOsm/L in the medulla
B300 to 1200 mOsm/L in the medulla
CAlways 300 mOsm/L like blood plasma
DAlways 1200 mOsm/L like inner medulla
Answer & Solution
Correct answer: B. 300 to 1200 mOsm/L in the medulla
The corticomedullary osmotic gradient runs from ~300 mOsm/L in the cortex to ~1200 mOsm/L in the inner medulla. NaCl and urea recycling produce the gradient. Human kidneys can concentrate urine to about 4x plasma.
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