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Mutant haemoglobin in sickle-cell anaemia polymerises under low oxygen and changes RBC shape from

ABiconcave disc to sickle
BSphere to flat disc
CDisc to cube shape
DSickle to biconcave disc
Answer & Solution
Correct answer: A. Biconcave disc to sickle
Under low oxygen tension the polymerised haemoglobin distorts the biconcave red cell into an elongated sickle.
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