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If NAD+ is unavailable, the second half of glycolysis:
ARuns unchanged
BRuns twice as fast
CSlows down or stops
DReverses direction
Answer & Solution
Correct answer: C. Slows down or stops
1. Step six needs NAD+ to accept the electrons stripped from the sugar.
2. NADH must be continuously oxidized back into NAD+ in order to keep this step going.
3. If NAD+ is not available, the second half of glycolysis slows down or stops.
4. That dependence is why fermentation exists: it regenerates NAD+ when oxygen is absent.
_Source: OpenStax Biology for AP(R) Courses (CC BY 4.0), Ch 7 'Cellular Respiration', sections 7.1-7.7_
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