In type 2 diabetes the oxidation efficiency of NADH is reduced, which affects:

1. NADH delivers its electrons at the start of the electron transport chain. 2. A problem in oxidising NADH therefore hits the pathway that depends on that delivery. 3. In type 2 diabetes the oxidation efficiency of NADH is reduced, impacting oxidative phosphorylation but not the other steps of respiration. 4. Glycolysis and the citric acid cycle keep running as long as NAD+ is regenerated. 5. So the effect is specific rather than uniform. _Source: OpenStax Biology for AP(R) Courses (CC BY 4.0), Ch 7 'Cellular Respiration', sections 7.1-7.7_