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Which enzyme cleaves fructose-1,6-bisphosphate into two three-carbon molecules?
AThe aldolase
BThe mutase
CThe hexokinase
DThe enolase
Answer & Solution
Correct answer: A. The aldolase
1. The six-carbon sugar must be split evenly for the second half of the pathway.
2. That split happens at step four.
3. The fourth step in glycolysis employs an enzyme, aldolase, to cleave fructose-1,6-bisphosphate into two three-carbon isomers.
4. Those isomers are dihydroxyacetone-phosphate and glyceraldehyde-3-phosphate.
_Source: OpenStax Biology for AP(R) Courses (CC BY 4.0), Ch 7 'Cellular Respiration', sections 7.1-7.7_
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