What has to break down before sister chromatids can separate in anaphase?

1. Cohesin is the protein that clamps the two sister chromatids together at the centromere. 2. While cohesin holds, the spindle can pull but the chromatids cannot come apart. 3. In anaphase the cohesin proteins are degraded. 4. The chromatids then separate and each is pulled toward its own pole. 5. Condensin coils the chromatids during prophase and is not what holds them together. _Source: OpenStax Biology 1e (CC BY 4.0), Chs 10 and 11, section 10.2 The Cell Cycle_