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What job does the kinetochore do during prometaphase?
AIt binds the spindle microtubules
BIt holds the sister chromatids
CIt builds the nuclear envelope
DIt coils the chromosome tightly
Answer & Solution
Correct answer: A. It binds the spindle microtubules
1. Each sister chromatid grows a kinetochore in the region of the centromere.
2. The kinetochore is built from protein and sits on the outside of the chromatid.
3. Its proteins attract spindle microtubules and bind them firmly.
4. Once bound, the chromosome can be steered by fibers reaching from both poles.
5. Holding the sister chromatids together is the job of cohesin, not the kinetochore.
_Source: OpenStax Biology 1e (CC BY 4.0), Chs 10 and 11, section 10.2 The Cell Cycle_
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