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Consider these lines: "Many people with sickle-cell anemia, and the particular genetic mutation that causes it, die at an early age. Despite the negative evolutionary effects associated with this genetic mutation, the sickle-cell gene remains relatively common among people of African descent. In parts of Africa where malaria is prevalent, having the sickle-cell mutation does provide health benefits for carriers." Based on the quoted lines, why does the gene stay common despite its costs?

ACarrying one copy protects against malaria where that disease is widespread
BThe mutation has stopped causing early deaths in modern Africa
CCarriers of the gene are immune to every tropical disease
DNatural selection cannot act on genes that cause disease
Answer & Solution
Correct answer: A. Carrying one copy protects against malaria where that disease is widespread
1. The quoted lines pose a puzzle: the mutation kills early, yet the gene stays relatively common. 2. The resolution arrives in the final sentence: where malaria is prevalent, carriers gain a health benefit. 3. That benefit offsets the cost, so the gene persists in exactly those places, which is option A. 4. Option C overreaches from one disease, malaria, to every tropical disease, a scope the quoted lines never claim. 5. Option B contradicts the opening sentence about early deaths, and option D contradicts the whole selection logic. _Source: OpenStax Psychology 1e (CC BY 4.0), Ch 3 "Biopsychology", section 3.1 Human Genetics_
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