Wobble hypothesis explains:
AWhy DNA double helix wobbles in solution
BThe pairing flexibility at the **third** (3') position of a codon, which underlies degeneracy
CRandom codon assignment
DWhy tRNAs sometimes fail to bind ribosomes
Answer & Solution
Correct answer: B. The pairing flexibility at the **third** (3') position of a codon, which underlies degeneracy
Crick's wobble hypothesis: the first two codon positions pair strictly with the anticodon, but the third can wobble — allowing a single tRNA to recognise multiple codons differing in the 3rd base. Explains why codons coding for the same amino acid often differ in the third base.
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In eukaryotes, primary mRNA transcript becomes mature mRNA afterThe 'one gene - one polypeptide' concept was proposed byIn prokaryotes, the small ribosomal subunit recognises the mRNA initiation site via theIn humans, the percentage of A in a DNA sample is 30 %. By Chargaff's rule, the percentageTranscription differs from replication in that itThe genetic code is described as degenerate becauseOkazaki fragments are formed on theDuring DNA replication, the enzyme that unwinds the double helix is