The place on an enzyme where its substrate binds is the:

1. An enzyme is a folded polypeptide with a specific three-dimensional shape. 2. One pocket in that shape does the catalytic work. 3. The location within the enzyme where the substrate binds is called the enzyme's active site. 4. The jigsaw-like match between that site and the substrate is what makes enzymes specific. _Source: OpenStax Biology for AP(R) Courses (CC BY 4.0), Ch 6 'Metabolism', sections 6.1-6.5_