As a cell grows larger, its surface area-to-volume ratio:

1. Volume grows with the cube of the radius while surface area grows only with the square. 2. So volume outruns surface area as size increases. 3. As a cell increases in size, its surface area-to-volume ratio decreases. 4. This matters because nutrients and wastes are always exchanged at the periphery of the cell. _Source: OpenStax Biology for AP(R) Courses (CC BY 4.0), Ch 4 'Cell Structure', sections 4.1-4.6_