Which inherited immunodeficiency knocks out both the B cell and the T cell arms of adaptive immunity?

1. Inherited immunodeficiencies arise from gene mutations that affect specific components of the immune response. 2. The most serious of them is severe combined immunodeficiency disease, which is caused by many different genetic defects. 3. What groups those defects together is that both the B cell and T cell arms of the adaptive immune response are affected. 4. Children with this disease usually die of opportunistic infections within their first year of life unless they receive a bone marrow transplant. 5. Lupus is an over-reaction rather than a deficiency, and immune deficiency acquired from a virus such as HIV is not inherited. _Source: OpenStax Anatomy and Physiology (CC BY 4.0), Ch 21 "The Lymphatic and Immune System", section 21.6 Diseases Associated with Depressed or Overactive Immune Responses_