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Thalassemia differs from sickle-cell anaemia in that:
AThalassemia is a *quantitative* defect (too few globin molecules synthesised); sickle-cell is a *qualitative* defect (an abnormally functioning globin)
BThalassemia is X-linked, sickle-cell is autosomal
CThalassemia is dominant, sickle-cell is recessive
DThalassemia is curable, sickle-cell is not
Answer & Solution
Correct answer: A. Thalassemia is a *quantitative* defect (too few globin molecules synthesised); sickle-cell is a *qualitative* defect (an abnormally functioning globin)
Both are autosomal recessive blood disorders, but: **Thalassemia = quantitative** (reduced rate of α- or β-globin synthesis); **sickle-cell = qualitative** (incorrect Glu→Val substitution producing dysfunctional Hb).
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